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產品名稱：ADCY6 Positive Control for STJ502058 peptide (STJ504557)
產品型號：STJ504557-5
產品廠商：ST john's laboratory
產品文檔：

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簡單介紹：

ADCY6 Positive Control for STJ502058 peptide (STJ504557)

詳情介紹：

Applications:	WB
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	ADCY6 Positive Control for STJ502058 is synthetically produced from the sequence and is suitable for use in western blot applications.

Formulation:	Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range:	WB: 1:500
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	Adcy6
Gene ID:	25289
Uniprot ID:	ADCY6_RAT
Specificity:	This is positive control is recommended for use in combination with ADCY6 antibody STJ502058.

Tissue Specificity	Detected in brain and kidney. Detected in vascular smooth muscle cells.
Post Translational Modifications	Phosphorylation by RAF1 increases enzyme activity. Phosphorylation by PKA on Ser-660 inhibits the GNAS-mediated increase in catalytic activity. Phosphorylation by PKC on Ser-554, Ser-660 and Thr-917 inhibits catalytic activity.
Function	Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion. Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function. Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol. Contributes to bone cell responses to mechanical stimuli.
Peptide Name	Adenylate Cyclase Type 6 Atp Pyrophosphate-Lyase 6 Adenylate Cyclase Type Vi Acvi Adenylyl Cyclase 6 Ac6 Ca(2+-Inhibitable Adenylyl Cyclase
Database Links	Reactome: R-RNO-163615 Reactome: -RNO-170660 Reactome: -RNO-170670 Reactome: -RNO-400042 Reactome: -RNO-418597 Reactome: -RNO-5610787
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Cell Projection Cilium Stereocilium
Alternative Peptide Names	Adenylate Cyclase Type 6 protein Atp Pyrophosphate-Lyase 6 protein Adenylate Cyclase Type Vi protein Acvi protein Adenylyl Cyclase 6 protein Ac6 protein Ca(2+-Inhibitable Adenylyl Cyclase protein Adcy6 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：ADCY6 Positive Control for STJ502058 peptide (STJ504557)