ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in its gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis.

Target	Alsin (ALS2)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 1248-1277 amino acids from the C-terminal region of human ALS2.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q96Q42 (UniProt, ExPASy)
UniProt Secondary AC	Q53TT1, Q53TV2, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9
UniProt Entry Name	ALS2_HUMAN
KEGG	hsa:57679
String	9606.ENSP00000264276
Molecular Weight	Calculated MW: 184 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat ALS2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Alsin (ALS2)